Fesca is a surname. Notable people with the surname include:

Alexander Fesca (1820−1849), German composer and pianist Friedrich Ernst Fesca (1789−1826), German violinist and composer Max Fesca (1846−1917), German specialist in agricultural science and agronomy

See also the Marconi-San Girolamo-Fesca Fédération du scoutisme centrafricain (FESCA)