Letta is an Italian surname and an African given name. It may refer to:
Gianni Letta (born 1935), an Italian politician and member of Forza Italia Enrico Letta (born 1966), Prime Minister of Italy Lencho Letta, Ethiopian politician, activist and founding member of Oromo Liberation Front Letta Mbulu, a South African jazz singer
See also Lettiani, the Democratic Party faction around Enrico Letta Henrietta (Letta) Crapo Smith (1862-1921), American painter, granddaughter of the former Michigan Governor, Henry H. Crapo