William Grimes may refer to:
William Alvan Grimes (1911–1999), Chief Justice of the New Hampshire Supreme Court William C. Grimes (Oklahoma politician) (1857–1931), American politician and businessman William C. Grimes (Florida politician) (1918–2007), member of the Florida House of Representatives William Grimes (journalist) (born 1959), former restaurant critic and current obituary writer for The New York Times W. F. Grimes (1905–1988), Welsh archaeologist William Grimes (footballer) (1886–?), English professional footballer for Bradford City and Derby County William Grimes (former slave) (1784–1865), author of what is considered the first narrative of an American ex-slave, Life of William Grimes, the Runaway Slave William P. Grimes (1868–1939), American politician in Wisconsin Billy Grimes (1927–2005), American football player
See also Willie Grimes (disambiguation)