George Kane may refer to:
George Proctor Kane (1820–1878), mayor of Baltimore, Maryland, 1877–1878 George Kane (American football) (1891–1969), American football player George Kane (literary scholar) (1916–2008), Canadian literary scholar George Francis Kane (born 1948), American chess player and writer George Kane (director), Irish film and television director
See also George Cain (1943–2010), author George Caines (1771–1825), first official reporter of cases in the United States George Cane (1881–1968), British diver