Mather House may refer to:

Mather House (Case Western Reserve University), classroom building Mather House (Convent, Louisiana), 1811 home Mather House (Harvard University), residence Call House, also known as the Henry R. and Mary Hewitt Mather House, Marquette, Michigan Mather House Museum, Port Jefferson, New York Mather-Kirkland House, Austin, Texas, listed on the NRHP in Travis County, Texas Stephen Tyng Mather Home, also known as Mather House or Mather Homestead, Darien, Connecticut

See also Mather Estate House, Perrysburg, Ohio, designed by Mills, Rhines, Bellman & Nordhoff Mather Homestead (Hartford, Connecticut), listed on the NRHP in Hartford, Connecticut Mather Inn, Ishpeming, Michigan William Mathers House, Carlisle, Kentucky, listed on the NRHP in Nicholas County, Kentucky