Chromonychia is an abnormality in color of the substance or surface of the nail plate or subungual tissues.Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. .
Chromonychia can be induced by antineoplastic drugs with few distinct forms, the most frequently seen is melanonychia. Although a few cytostatics may cause these changes, the drugs most commonly involved are adriamycin, cyclophosphamide and vincristine, or in polychemotherapy
Also chromonychia is associated with AIDS. A significant association (p<0.05) was found between chromonychia and CD4 counts of below 200 per cubic millimeter.
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