HDX may refer to: HDX (Home Depot), in-house brand used by The Home Depot Fire HDX, Amazon Fire tablet computer Half-duplex, communication flowing in both directions, but not simultaneously Humanitarian Data Exchange, an open humanitarian data sharing platform managed by the United Nations Office for the Coordination of Humanitarian Affairs Hydrogen–deuterium exchange Lisofylline, an experimental anti-inflammatory drug Pro Tools HDX audio accelerator hardware Thomas Saf-T-Liner HDX, an American school bus Sky Sports HDX, a defunct Sky Sports HD channel brand