Route 59 may refer to:

Route 59 (MTA Maryland), a bus route in Baltimore, Maryland and its suburbs Route 59 (MBTA), a bus route in Massachusetts London Buses route 59 Melbourne tram route 59 SEPTA Route 59, a trackless trolley in Northeast Philadelphia Route 59 station, a Metra train station along the BNSF Line on the border of Aurora, Illinois and Naperville, Illinois

See also List of highways numbered 59