Route 22 is a common name for roads and highways in many countries.

Route 22 may also refer to:

Route 22 (MTA Maryland), a bus route in Baltimore, Maryland, U.S. Route 22 (MBTA), a bus route in Boston, US London Buses route 22, a bus route in London, UK Melbourne tram route 22, a former tram route in Melbourne, Australia 22 Fillmore, a bus route in San Francisco

See also Line 22 (disambiguation)