In public transport, Route 5 may refer to:
North America Canada Line 5 Blue (Montreal Metro)
United States 5 (New York City Subway service) 5 (New Jersey bus), a New Jersey Transit bus route Route 5 (MTA Maryland), a bus route in Baltimore, Maryland 5 (Los Angeles Railway), a line operated by the Los Angeles Railway from 1931 to 1958 5 Fulton, a bus route in San Francisco
Mexico Mexico City Metro Line 5
Europe Spain Barcelona Metro line 5 Line 5 (Madrid Metro)
United Kingdom London Buses route 5
Asia China Citybus Route 5, a bus route in Hong Kong
Malaysia Kelana Jaya Line, numbered 5 on transit maps
South Korea Seoul Subway Line 5
Oceania Australia Melbourne tram route 5
See also Line 5 (disambiguation)