Santelli is an Italian surname. Notable people with the surname include:
Alberto Santelli (born 1953), Uruguayan soccer player Benjamin Santelli (born 1991), French soccer player Claude Santelli (1923–2001), French film director and screenwriter Giorgio Santelli (1897–1985), Italian fencer Giuseppe Santelli (1880–1956), Italian painter Italo Santelli (1866–1945), Italian fencer Jole Santelli (1968–2020), Italian politician Paul Santelli (1898–1928), French flying ace Rick Santelli (born 1956), American editor