Xerxes ( ) may refer to:

People Xerxes I of Persia, "Xerxes the Great", reigned 486–465 BC Xerxes II of Persia, briefly reigned 424 BC Xerxes of Sophene, ruler of Sophene and Commagene, 228–201 BC Xerxes (Sasanian prince), 6th-century prince and general Xerxes (name), a list of people with the name

Fiction, stage and video Il Xerse (Xerxès in its 1660 French version), a 1654 opera by Francesco Cavalli Xerse (Bononcini), a 1694 opera by Giovanni Bononcini Serse (Xerxes), a 1738 opera by George Frideric Handel Xerxes, a 1919 novel by Louis Couperus Xerxes (TV series), a 1988 Swedish TV series about young adults Xerxes (graphic novel), a 2018 graphic novel by Frank Miller

Other Xerxes Peak, a mountain in the Canadian Rockies XerxesDZB, a Dutch formerly professional football team based in Rotterdam Roksan Xerxes, a series of record turntables from Roksan Audio (UK) XerXeS, a denial-of-service attack tool developed by The Jester XERXES, a computer AI in System Shock 2 Xerxes, a 1994 album by Arcwelder Xerxes (plant), a genus of flowering plants in the aster family

See also Ahasuerus, a related name used in the Hebrew Bible, legends and Apocrypha Artaxerxes I of Persia, reigned 465–424 BC Xerces (disambiguation)