Guy Johnson may refer to:

Guy Johnson (c. 1740–1788), military officer and diplomat for the Crown during the American Revolutionary War Guy Johnson (politician) (died 1965), American politician and educator Guy Johnson (baseball player) (1891–1971), who built the Mystic Theatre (Marmarth, North Dakota) Guy Benton Johnson (1901–1991), American sociologist and social anthropologist Guy Johnson (businessman), English businessman Guy Johnson (journalist), journalist at Bloomberg L.P. Detective Guy Johnson, a movie character played by James Stewart in It's a Wonderful World Guy Johnson (born Clyde), son of author Maya Angelou

See also Guy Johnston (born 1981), British cellist