The Open Notebook Science Challenge is a crowdsourcing research project which collects measurements of the non-aqueous solubility of organic compounds and publishes these as open data; findings are reported in an open notebook science manner. Although anyone may contribute research data, the competition is only open to post-secondary students in the US and UK.
The challenge in turn forms part of the UsefulChem project, an ongoing open notebook science effort to synthesize and screen potential new anti-malarial drugs.UsefulChem Data from the Solubility Challenge will be used to build predictive computational models of solubility for use in optimising syntheses.ONS solubility modeling and prediction
The challenge began on September 28, 2008The beginning of the Open Notebook Science challenge and, as of February 2014, involves researchers and their students from at least 4 different institutionsList of experiments and has resulted in the acquisition of over 7672 solubility measurements.[lxsrv7.oru.edu/~alang/onsc/chemspace/cs.php Solubility of Organic Compounds in Organic Solvents]
Prizes
To encourage participation, each month an awardA News Story Discussing the Awards is given to the student who does, in the opinion of the judges,ONS Challenge judges the best work. In order to participate, students have to be a US or UK resident.ONS Challenge Rules The award is a US$500 cash prize. The first three winners also received a year's subscription to the journal Nature. The awards are sponsored by Submeta and Nature.
Request an experiment
As well as concentrating on compounds related to the Ugi reaction, the ONSchallenge allows anyone to request a solubility measurement experiment.[lxsrv7.oru.edu/~alang/onsc/solubility/solubility.php request a solubility measurement experiment]
Chemical donations
Sigma Aldrich is also an official sponsor of the Open Notebook Science Challenge. Sigma Aldrich is participating by donating and shipping requested chemicals to any experimenters in the US or UKSigma Aldrich's involvement with the ONS challenge for free.
References
External links Open Notebook Science Challenge