The logo and uniforms of the San Francisco 49ers have evolved since their inception in 1946.

The early years (1946–1963) The 49ers changed uniform designs and color combinations quite often in their first eighteen years of existence. From the team's inception in 1946 through the early 1960s, the San Francisco 49ers usually wore red, white or silver helmets, white or light-gray pants, and cardinal red (home) and white (road) jerseys. The 49ers' original logo was a mustached 49er gold miner from the 1849 California Gold Rush, dressed in plaid pants and a red shirt, jumping in midair with his hat falling off, and fired pistols in each hand: one nearly shooting his foot, and the other pistol forming the word "Forty-Niners" from its smoke. By the mid-1950s this logo showed the prospector jumping against a backdrop of Kezar Stadium, the team's home from 1946 to 1970.

Original uniforms consisted of plain red jerseys with white front and back numerals and no trim. Pants were white, and leather helmets were in several colors. In 1950, concurrent with the team's admission to the NFL, the red jersey gained three parallel white stripes on the sleeves; this feature, with modifications and updates, has been implemented on the team's jersey ever since. Also around this time, the helmets were gradually changed over to a silver-colored plastic. An entirely new look appeared in 1953; helmets were red with a silver center stripe. White pants were given a thin red-black-red tri-stripe. For the 1954 season silver-grey pants were introduced, and in the 1955 season the jersey numerals gained black trim that created a "dropshadow" effect. These 1955 jerseys, along with white pants, served as the model for the team's "throwback" uniform in its championship 1994 season. Red socks included three white stripes. In 1956 the helmet was changed to solid white and the black outlining and shadowing effect was eliminated from the jersey numerals. The pants striping became solid red. In 1957 the 49er uniform was altered again; helmets were made gold, accompanied by beige-gold, unstriped pants. Jerseys and socks remained the same, but in accordance with the NFL's 1957 rule ordering primary-colored "home" and light "road" shirts for each team, the 49ers debuted white road jerseys with three parallel sleeve stripes; the middle stripe was red, the top and bottom gold. This striping was replaced in 1958 by a wide red crescent shoulder stripe. So-called "TV Numbers" appeared on both jerseys in the same year.

Throughout the middle and late 1950s, and the early 1960s, the 49ers were one of just a few NFL teams (the Chicago Bears were most prominent) to use helmets made by Chicago-based Wilson Sporting Goods; these helmets were of slightly different shape than those made by the Riddell company, which for more than a half-century have been a prominent supplier of NFL team headgear. Yet another radical alteration was made to the 49er uniform in 1960. Appearing were silver helmets with three widely spaced red stripes; the center stripe was thicker. Home jerseys were unchanged, but road jerseys featured a new dual crescent shoulder stripe in what is usually called the "UCLA" style. An alternate logo was designed in the 1960s featuring a shield-shaped crest formed from the number "49", with a football in the upper right quadrant and "SF" in the lower left quadrant. In 1962 the helmet was redesigned to feature a red-white-red triple center stripe (the white middle stripe was wider). The earliest version of San Francisco's current primary logo, an intertwined white "SF" within the center of a red oval, also debuted in the 1962 helmet design. By 1972-73 the oval was slightly smaller in size and gained a thicker black border.

A more standard look (1964–1988) The team's colors then changed in 1964. All silver elements were changed to what was called "49ers Gold;" helmets were gold, with the same striping and logo. New beige-gold pants with a red-white-red Tristripe in the same style as the helmet were introduced. The scarlet red jerseys kept the traditional three white sleeve stripes, but road jerseys abandoned the previous dual crescent shoulder stripes in favor of three red sleeve stripes (the converse of the home jersey). The red home jerseys had white block numbers, three white parallel stripes on the sleeves, and smaller white block "TV" numbers above these stripes on the upper sleeve, with the color scheme reversed for the white road jersey. The red elliptical helmet logo was made slightly smaller in 1971-72 and received a thicker black border around the oval. From 1964 to 1971, the team's gold pants were unique in that they consisted of two varying colored panels: a more lustrous gold fabric was used on the rear portion of the pants and a lighter-hued, less lustrous beige fabric on the front. This pants design was abandoned from 1972 onwards for a more uniform, subdued beige. On very few occasions from 1971-1973, when traveling to play against teams in warm-weather venues that wore white jerseys at home such as the Los Angeles Rams and New Orleans Saints, the 49ers would don thinner mesh-fabric red jerseys that were missing the usual sleeve stripes and TV numbers. There was also a white version of this warm-weather jersey that was worn on even rarer occasions.

The 1964 uniform's basic design would be worn for practically the next thirty seasons with only some minor changes and adjustments, such as a gradual change over from sans-serif to serifed block numerals from 1970–74 and a switch from thin stripes to a very thick pant striping in 1976 (during which white jerseys were also worn at home for most of that season). The uniform ensemble of red and white jerseys, and beige-gold pants with thick striping would be worn until 1995 (as well as for throwback games from 2002–08). Starting in 1984, there was a change in the numeral font (the number "2" was made a squarer block numeral), along with the gradual incorporation of serifed letters for players' names on the back of the jerseys (completed by the 1986 season). Also for the 1986 season, the 49ers incorporated a special 40th anniversary patch sewn on the pants along the side of the hips. At the conclusion of the 1988 season, in what would be Coach Bill Walsh's final game, five 49ers (including quarterback Joe Montana) would wear red jerseys from circa the 1984 season (distinguishable by thicker sleeve stripes and sans-serif lettering for players' names) during the team's Super Bowl XXIII victory.

1989–1993

In 1989, the 49ers' jerseys were further slightly altered with the stripes on the sleeves being made less bold and arranged closer together (sleeves on NFL jerseys began to get shorter and closer to the shoulder around this time). As for the team's helmet logo, black outlining on the intertwined "SF" was also added in 1989. For the 1991 season, concurrent with the rest of the teams in the NFL, the 49ers incorporated a small NFL Shield logo sewn on the bottom of the jersey's collar and front of the pants for the first time (this would be replaced with a redesigned "NFL Equipment" Shield logo for the 2002 season).

Prior to the 1991 season, the 49ers announced a prototype for a new logo and helmet design. Instead of the traditional "SF" oval, this new logo featured a stylized "49ers" in white with black and red shadows, along with a red facemask. However, fan reaction was so overwhelmingly negative that the idea was scrapped the next day. The only carryover from the 1991 planned uniform change (and the last significant change to the 1964–1995 uniform design) was the switch from red socks with three white stripes to solid red socks.

1994–1995 During the 1994 season, many NFL teams wore "throwback uniforms" in occasional games (beginning with week 3 of the season) to celebrate the NFL's 75th anniversary (a corresponding diamond-shaped 75th Anniversary patch was also worn by all teams). The 49ers chose to wear a version of their 1955 uniforms as their throwbacks, with simpler sans-serif block numerals that had black outlines and blockshadows (the smaller TV numerals above the shoulder stripes however, were removed as they were non-existent on the original 1950s jerseys). White pants with thinner red-black-red striping were also worn, along with the old striped red socks (the team later reverted to their regular solid red socks after receiving permission from the NFL to wear the uniforms for the rest of the season). The regular 1989–95 design gold helmet was worn with this uniform, as there was no logo on the 1955 red helmet.

The team first donned the 1955 throwback uniforms during their week 3 match against the Los Angeles Rams and the following week at home versus the Saints, with both being wins (coincidentally, these were also the first two games Deion Sanders played after signing as a free-agent with the 49ers). The team then suffered an embarrassing 40–8 loss to the Philadelphia Eagles at home wearing their regular uniforms with gold pants, with Steve Young angrily being benched to prevent his injury. For the subsequent three games until their bye week, the team again was scheduled to play games wearing the throwback uniforms with white pants and blockshadow numerals, and all three games resulted in wins. As the 49ers embarked during the following weeks on what would eventually be a 10-game winning streak that ultimately culminated in a Super Bowl XXIX victory, the team (prompted both by the superstition of then coach George Seifert, as well as the preference of players) petitioned the NFL to wear the throwback uniforms for the rest of the season, which was granted. The switch to solid red socks after the team's BYE week in the middle of the season marked this occurrence. In all the 49ers went 15–1 (including the playoffs) wearing the 1955/1994 throwback uniforms (the only loss being the regular season finale on the road at Minnesota, with the team wearing white jerseys and resting most of their starters for the playoffs). Meanwhile, the 49ers went undefeated wearing the red jerseys of the throwback uniform. After winning Super Bowl XXIX, however, the team was compelled to revert to wearing its regular 1964-style uniforms (1991 revised design) for the following 1995 season.

1996: 50th Anniversary Uniform change In 1996, the 49ers celebrated their 50th anniversary by designing a commemorative jersey patch based on the earlier shield-crest logo. The team also debuted a substantially new uniform design, most notably changing the shade of red used in their jerseys from bright scarlet to a deeper, cardinal red. The smaller TV numerals were moved from the side of the upper sleeve above the sleeve striping to the top of the shoulderpads. Other new modifications to the uniform showed marked influence from the 1994 throwback uniforms: a black blockshadow effect (along with gold trim) was added to the jersey numerals (which remained in the blocked serif style). Black trim was added on the sleeve stripes as well, which also now featured an updated oval "SF" logo. The team's helmet underwent a major redesign as well in 1996. The updated oval logo (now in cardinal red) had a more stylized, "stretched" black border along with gold trimming, while the intertwined "SF" had thicker black bordering and shadows. For the helmet's color a shinier, more metallic gold was used, while the helmet striping was changed from red-white-red to black-cardinal-black. The old gray-colored facemask was also switched to a cardinal-red colored one. As in 1994, the Niners donned white pants full-time for the 1996 season (also wearing them for the 1996 season and 1997 preseason,) though this time the pant stripes were marginally thicker and the colors were reversed to black-cardinal red-black (matching the striping on the helmets). The socks remained solid-colored, though switched to the darker cardinal red.

2006–2008