John McCloskey (1810–1885) was an American Roman Catholic clergyman and first American Cardinal.
John McCloskey may also refer to:
John McCloskey (baseball manager) (1862–1940), American baseball manager John McCloskey (pitcher) (1882–1919), American baseball pitcher C. John McCloskey, Catholic priest Jack McCloskey (1925–2017), American basketball player, coach and executive
See also H. J. McCloskey (Henry John McCloskey, 1925–2000), Australian moral philosopher