Sapunov, feminine Sapunova () is a Russian and Ukrainian surname. Notable people with the surname include:
Danylo Sapunov (born 1982), Kazakhstani and Ukrainian triathlete Nikolai Sapunov (1880–1912), Russian painter Tatyana Sapunova (born 1974) a Russian biophysicist Yulia Sapunova Yelistratova (born 1988) a professional Ukrainian triathlete