Acquired hemolytic anemia can be divided into immune and non-immune mediated forms of hemolytic anemia.
Classification Immune Autoimmune hemolytic anemia Warm antibody autoimmune hemolytic anemia Idiopathic Linked with primary immunodeficiency/immunodysregulation syndrome. Lymphoma or chronic lymphocytic leukemia associated. Secondary to other malignancies. Associated with SLE or other collagen-vascular disorders. Secondary to viral infection. Cold antibody autoimmune hemolytic anemia Paroxysmal cold hemoglobinuria Drug-induced autoimmune hemolytic anemia Alloimmune hemolytic anemia Hemolytic disease of the newborn (HDN) Rh disease (Rh D) ABO hemolytic disease of the newborn Anti-Kell hemolytic disease of the newborn Rhesus c hemolytic disease of the newborn Rhesus E hemolytic disease of the newborn Other blood group incompatibility (RhC, Rhe, Kidd, Duffy, MN, P and others) Alloimmune hemolytic blood transfusion reactions (i.e., from a non-compatible blood type)
Non-immune Traumatic hemolytic anemia Impact Macrovascular defects-prostheses Microvascular causes Disseminated intravascular hemolysis Thrombotic thrombocytopenic purpura Typical and atypical hemolytic uremic syndrome Other microvascular abnormalities Hypersplenism Hemolytic anemia due to toxic effects on the membrane Spur cell anemia External toxins Animal or spider bites Metals Organic compounds Infectious agents Paroxysmal nocturnal hemoglobinuria (PNH)
History The term 'acquired hemolytic anemia' originally appeared in the early 1900s.
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