Ruffer is an English surname. Notable people with the surname include:
Jonathan Ruffer (born 1951), British fund manager and philanthropist Marc Armand Ruffer (1859–1917), Swiss-born English experimental pathologist Maurice Ruffer (1857–1935), French-born British banker Corinna Rüffer (born 1975), German politician
See also Ruffer Investment Company, investment company listed on the London Stock Exchange A Ruffer & Sons, defunct family bank