Porzio is an Italian surname that may refer to:
Alfredo Porzio (1900–1976), Argentinian boxer Camillo Porzio (1526–1580), Italian historian Francesco Porzio (born 1966), Italian water polo player Giovanni Porzio (1873–1962), Italian politician and lawyer Lorenzo Porzio (born 1981), Italian rower Mike Porzio (born 1972), American baseball player Nino Porzio (born 1972), Italian singer and actor Pino Porzio (born 1967), Italian water polo player Simone Porzio (1496–1554), Italian philosopher