The Missouri State Bears baseball team represents Missouri State University, which is located in Springfield, Missouri. The Bears are an NCAA Division I college baseball program that competes in Conference USA. They began competing in Division I in 1983, and joined the Missouri Valley Conference in 1991 after seven seasons with the Mid-Continent Conference. They joined Conference USA in 2025.

The Missouri State Bears play all home games on campus at Route 66 Stadium. Under the direction of former head coach Keith Guttin, the Bears have played in 12 NCAA Tournaments, and they reached the College World Series in 2003. Over their 29 seasons in the Missouri Valley Conference, they have won six MVC regular-season titles and four MVC tournaments.

Since the program's inception in 1964, 20 Bears have gone on to play in Major League Baseball, highlighted by three-time All-Star and 2006 NL MVP Ryan Howard.

Missouri State in the NCAA Tournament 1987 0–2 West II Regional 1995 0–2 West Regional 1996 2–2 Central I Regional 1997 2–2 Central Regional 1999 2–2 Fayetteville Regional 2002 2–2 Lincoln Regional 2003 5-3 College World Series 7th place, Columbus Super Regional Champions, Lincoln Regional Champions 2012 1–2 Coral Gables Regional 2015 4–2 Fayetteville Super Regional, hosted Springfield Regional 2017 3-3 Fort Worth Super Regional, Fayetteville Regional Champions 2018 1–2 Oxford Regional 2022 1–2 Stillwater Regional 2026 0–2 Lawrence Regional 23-30

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