Reticular pigmented anomaly of the flexures (also known as dark dot disease and Dowling–Degos disease) is a fibrous anomaly of the flexures or bending parts of the axillae, neck and inframammary/sternal areas.James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. . It is an autosomal-dominant pigmentary disorder that may appear in adolescence or adulthood. This condition is due to mutations in structural/desmosomal proteins found within stratified squamous epithelium.
Dark dot disease is associated with KRT5.
See also List of cutaneous conditions List of cutaneous conditions caused by mutations in keratins Skin lesion
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