Otis House may refer to: Otis House (Prescott, Arizona), listed on the NRHP in Yavapai County, Arizona First Harrison Gray Otis House, Boston, MA, listed on the NRHP in Massachusetts Second Harrison Gray Otis House, Boston, MA, listed on the NRHP in Massachusetts Third Harrison Gray Otis House, Boston, MA Otis-Wyman House, Somerville, MA, listed on the NRHP in Massachusetts