Joe Hughes may refer to:
Joe Hughes (baseball) (1880–1951), baseball player for the Chicago Cubs Joe Hughes (boxer) (born 1990), British boxer Joe Hughes (British Army soldier) (died 1946), British recipient of the George Cross Joe Hughes (footballer) (1898–?), Welsh professional footballer Joe "Guitar" Hughes (1937–2003), American blues musician Joe Hughes (quarterback), born c. 1972, Wyoming Cowboys quarterback
See also Joseph Hughes (disambiguation)