McCombe is a (patronymic or paternal) family name. Variants of which include: McColm, McComb, McComber, McCome and McKomb.

McCombe is one of the sept names of the Scottish Clan MacThomas.

Notable people with this surname (or similar) include: Alan McCombes (born 1955), Scottish politician Jamie McCombe (born 1983), English football (soccer) defender Jim McCombe (1932–2011), Leader of the Golden Hawks RCAF air demonstration team John McCombe (born 1985), English football (soccer) defender Lt-Col John McCombe of the Royal Corsican Rangers John McComb Jr. (1763–1853), Architect of New York City Hall and many other buildings in NY and NJ Leonard McCombe (1923–2015), Manx-born American photojournalist