James Humphreys may refer to:
James Humphreys (printer) (1748–1810), American-born publisher & politician James Humphreys (lawyer) (c. 1768–1830), British lawyer, writer and law reformer James Humphreys (pornographer) (1930–2003), British operator of adult book shops and strip clubs James E. Humphreys (1939–2020), American mathematician James Humphreys (author) (born 1967), British political strategist and fiction writer Jimmy Humphreys (1894–1956), Irish hurler
See also James Humphrey (disambiguation) Jimmie Humphries (1890–1971), American baseball player