Van Antwerp is a surname. Notable people with the surname include:
Edith Chesebrough Van Antwerp (1881–1949), American golfer Eugene Van Antwerp (1889–1962), American mayor Howard Van Antwerp (1898–1992), American football player and attorney Jack Van Antwerp (born 1963), American photojournalist Robert L. Van Antwerp, Jr. (born 1950), United States Army general Verplanck Van Antwerp (1807–1875), United States Union Army general
See also Van Antwerp Building, skyscraper in Mobile, Alabama