Sleeping sickness may refer to:
Medical conditions African trypanosomiasis, also known as African sleeping sickness, is a vector-borne parasitic disease Animal trypanosomiasis, also known as nagana or animal African trypanosomiasis Eastern equine encephalitis virus, a zoonotic alphavirus and arbovirus present in North, Central and South America and the Caribbean Encephalitis lethargica, a form of encephalitis that swept the world in the 1920s, also known as "sleepy sickness" Sleeping sickness of Kalachi, Kazakhstan or "sleepy hollow", a conjectured medical condition which causes long bouts of sleep, at some point present in just two villages in Kazakhstan
In arts and entertainment Sleeping Sickness (film), a 2011 German film "Sleeping Sickness" (song), a 2008 song by the band City and Colour