Dessaulles is a French Canadian surname. Notable people with the surname include:
Caroline Dessaulles-Béique (1852–1946), Canadian social activist and feminist Georges-Casimir Dessaulles (1827–1930), businessman, statesman, and Canadian senator Henriette Dessaulles (1860–1946), Canadian journalist and diarist from Quebec, pioneer of women's writing in Quebec Jean Dessaulles (1766–1835), seigneur and political figure in Lower Canada Louis-Antoine Dessaulles (1818–1895), Quebec seigneur, journalist, and political figure