Line 100 (numbered 900 until 2021) is one of CFR's main lines in Romania, having a total length of about . The main line, connecting Bucharest with the western city of Timișoara, passes through the important cities of Craiova, Drobeta-Turnu Severin and Lugoj.
There are five pairs of direct trains that run daily on the Bucharest North–Timișoara route; four of those trains belong to the state railway operator CFR Călători and one to the private operator . The journey takes approximately 10 hours.
Secondary lines Line Terminal stations Intermediate stops Length 101 Bucharest North Craiova Titu – Pitești – Costești – Slatina – Piatra Olt – Balș 250 102 Bucharest Progresu Giurgiu 61 103 Videle Giurgiu 66 104 Titu Pietroșița Târgoviște 67 105 Golești Câmpulung 55 106 Pitești Curtea de Argeș 38 107 Roșiori North Costești 64 108 Roșiori North Turnu Măgurele 50 109 Roșiori North Zimnicea Alexandria 78 110 Piatra Olt Corabia Caracal 74 112 Craiova Calafat 108 113 Golenți Poiana Mare 7 114 Strehaia Motru 31 115 Caransebeș Reșița South 43 116 Lugoj Jamu Mare Buziaș – Gătaia 84 117 Caransebeș Băuțar 37 118 Timișoara North Buziaș 119 Timișoara North Jimbolia 58 120 Jebel Liebling 10 121 Jebel Giera 33 122 Timișoara North Reșița South Jebel – Voiteg – Gătaia – Berzovia 98 123 Berzovia Oravița 59 124 Oravița Iam 27 125 Oravița Anina 33 126 Timișoara North Cruceni 49 127 Cărpiniș Otelec 31 128 Jimbolia Lovrin 27
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