CRL may refer to:
Organisations Science and technology research Chalk River Laboratories, a Canadian nuclear research center Charles River Laboratories, an American biomedical company Computational Research Laboratories, an Indian computer company CRL infrared sky survey
Sports leagues Canada Rugby League, the governing body for rugby league football in Canada Championship Racing League, a co-sanctioning arrangement between CART and USAC for the 1980 CART PPG Indy Car World Series Country Rugby League, governing body for rugby league football in rural New South Wales, Australia
Other organizations Canons Regular of the Lateran, a Catholic religious order Center for Research Libraries, a consortium of North American universities, colleges, and independent research libraries Co-operative Retail Logistics, part of the Co-operative Group Corsair International, formerly Corsairfly (ICAO airline designator) CRL Group, a British video game company
Science and technology
Certificate revocation list, in computing, a list of revoked certificates Chemistry Research Laboratory, University of Oxford, the main chemistry building at Oxford University Complete Response Letter, the official FDA response to a New Drug Application Crown-rump length, the ultrasound measurement of a foetus
Transportation infrastructure Brussels South Charleroi Airport (IATA code CRL) Chicago Rail Link, a shortline railroad in Chicago City Rail Link, a rail project in Auckland, New Zealand Cross Island Line, a planned mass transit line for Singapore
Other uses East Cree language (ISO 639-3 code crl) Certified Registered Locksmith, as awarded by the Associated Locksmiths of America Countrywide Residential Lettings Ltd, a property services group in the UK, owned by Countrywide