Diphenylbutylpiperidines are a class of typical antipsychotic drugs which were all synthesized, developed, and marketed by Janssen Pharmaceutica.
They include: Clopimozide (R-29,764) Fluspirilene (Redeptin) Penfluridol (Semap, Micefal, Longoperidol) Pimozide (Orap)
Additionally, Hoechst discovered R-56109 bearing the pendant ω-difluorophenylbutyl sidechain The piperidine portion of the molecule (R-56109) is of interest because it serves dual use in the synthesis of risperidone, paliperidone, ocaperidone, iloperidone, abaperidone and S18327. R-56109 was first invented by Hoechst (not Janssen) and appeared in a pair of patents on the butyrophenone design in 1982.
Diphenylbutylpiperazines Incorporating an additional nitrogen atom into the heterocyclic ring gives the closely related diphenylbutylpiperazines.
Examples of this include: Amperozide (antipsychotic) Lidoflazine PR-000608 FG5865 FG-5893 Mioflazine Difluanazine
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