Guillermo Franco may refer to:
Guillermo Franco (born 1976), Argentine-Mexican football striker Guillermo Franco (footballer, born 1983), Argentine football defender Guillermo Franco (Ecuadorian general) (1811-1873), Ecuadorian historical figure
See also Guillermo Francos (born 1950) Argentine politician and Chief of Cabinet from March 2024 to October 2025 Guilherme Franco (born 1946), Brazilian jazz percussionist