There are 16 National Natural Landmarks in Missouri.

Name Image Date Location County Ownership Description Big Oak Tree State Park East Prairie Mississippi state A rare untouched wet-mesic bottomland hardwood forest in the Mississippi Alluvial Plain, it is the home of several state and national champion trees Carroll Cave Camden private Contains a dendritic system of subsurface karst streams and tributaries. Cupola Pond Ripley federal One of the most ancient sinkhole ponds in the Ozark plateaus. Located in Mark Twain National Forest. Golden Prairie Golden City Barton private An unplowed remnant of the tall grass prairie ecosystem. Grand Gulf State Park Thayer Oregon state An excellent example of karst topography, this canyon is a collapsed dolomite cave with a natural bridge. Water in this canyon emerges away in Mammoth Spring, Arkansas. Greer Spring Oregon private Spring in the Ozarks that discharges into a high quality, cascading stream. Maple Woods Natural Area Clay state Contains a nearly virgin sugar maple and mockernut hickory forest. Maramec Spring St. James Phelps private A natural spring, the fifth largest in the state. It has a notable trout park and a historic iron works in a privately owned park. Mark Twain and Cameron Caves Marion private Exceptionally good examples of the maze type of cavern development. Marvel Cave Stone private Includes one of the greatest dripstone units of all the Ozark caves. Onondaga Cave State Park Crawford state Contains an unusually large and varied number of speleothems. Pickle Springs Ste. Genevieve state Contains one of the finest Pleistocene relict habitats in Missouri. Taberville Prairie Conservation Area St. Clair state One of the largest remaining virgin tall grass prairies. Tucker Prairie Callaway private A virgin tall grass prairie occurring within the transition zone between the oak-hickory forest and typical tall grass prairie. Tumbling Creek Cave Taney private Contains the most diverse fauna known for any cave west of the Mississippi River. Wegener Woods Warren private An essentially virgin oak-hickory-dominated forest in a condition of gradual change to a sugar maple-dominated forest.

See also List of National Historic Landmarks in Missouri List of Missouri state parks