Setoguchi () is a Japanese surname, meaning "mouth () of the channel ()". People with this surname include:
Devin Setoguchi (born 1987), Canadian former ice hockey player , Japanese footballer , Japanese idol , Japanese composer and conductor
Fictional characters with this surname include: Hina Setoguchi, a main character in 2016 Japanese animated film Suki ni Naru Sono Shunkan o
See also Setoguchi Station, railway station in Seto, Aichi Prefecture, Japan Setouchi (disambiguation), also a Japanese surname and placename 58622 Setoguchi, minor planet discovered in 1997
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