South Middleton can refer to:
South Middleton, Greater Manchester, a ward of Rochdale Borough Council, England South Middleton, Ilderton, a location in Northumberland, England South Middleton, Wallington Demesne, a former civil parish, now in Wallington Demesne, Northumberland, England South Middleton, Ontario, Canada South Middleton Township, Pennsylvania, USA
See also Middleton (disambiguation) North Middleton (disambiguation) West Middleton