Rustici is an Italian surname. Notable people with the surname include:
Cristoforo Rustici, known as il Rusticone, (1552 – 1641), Italian painter Francesco Rustici, known as Il Rustichino (c.1592 - 1625), baroque painter of the Sienese School Giovanni Francesco Rustici (1474-1554), Italian sculptor Marco di Bartolomeo Rustici (c.1393 - 1457), Florentine goldsmith Vincenzo Rustici (1556–1632) Italian painter
See also Rustici Codex or Codice Rustici, a miniature codex (1448-1450) saved in the library of the Grand Seminary of Florence Rustici Engine (SCORM)