Guo or GUO may refer to:
People Guo (郭), a Chinese surname Guo (surname 國), Chinese surname Consort Guo (disambiguation) Empress Guo (disambiguation) Prince Guo
Places Guo Prefecture (disambiguation) Eastern Guo, an ancient Chinese state Western Guo, an ancient Chinese state, divided into Northern Guo and Southern Guo
Other uses Guayabero language, a Guahiban language of Colombia Gualaco Airport, in Honduras Main Guard Directorate (Russian: ), a branch of the Soviet Union's KGB