Route 580, or Highway 580, may refer to:
Canada Alberta Highway 580 New Brunswick Route 580 Ontario Highway 580
United Kingdom A580 road
United States I-580 Interstate 580 (California), a spur connecting the San Francisco Bay Area to the San Joaquin Valley from U.S. Route 101 to Interstate 5 Interstate 580 (Nevada), a spur connecting Carson City, Nevada to Reno, Nevada (also signed as U.S. Route 395) Interstate 580 (Nebraska), a former route and now part of U.S. Route 75 in Omaha, Nebraska