George Klein may refer to:
George Klein (inventor) (1904–1992), Canadian inventor George Klein (comics) (c. 1915 or 1920 – 1969), American comic book artist George Klein (biologist) (1925–2016), Hungarian-Swedish biologist and writer George Klein (physician), Canadian cardiologist George Klein (DJ) (1935–2019), disc jockey and television host George Klein (Canadian football) (1932–?), Canadian football player George S. Klein (1917–1971), American psychologist and psychoanalyst Adam Klein (swimmer) (George Klein IV, born 1988), American swimmer
See also Georg Klein (disambiguation) George Klyne (1828–1875), Member of the Legislative Assembly of Manitoba George Kline (1921–2014), American philosopher, Russian scholar and academic