Little River may refer to the following rivers in the U.S. state of South Carolina:
Little River (Broad River), a tributary of the Broad River Little River (Horry County, South Carolina), flowing directly into the Atlantic Ocean Little River Inlet, the southern mouth of the above river Little River (McCormick County, South Carolina), a tributary of the Savannah River Little River (Oconee County, South Carolina), a tributary of the Keowee River Little River (Saluda River), a tributary of the Saluda River in Newberry and Laurens Counties