Dufresne or du Fresne () is a surname. Notable people with the surname include:
Armand A. Dufresne Jr. (1909–1994), Justice of the Maine Supreme Judicial Court Begoña Vía-Dufresne (born 1971), Spanish sailor and Olympic champion Bertrand Dufresne (1736–1801), French financier, civil servant and politician Charles Dufresne (1876–1938), French painter Chris Dufresne (1958–2020), American sports journalist Diane Dufresne (born 1944), Canadian singer and painter Donald Dufresne (born 1967), retired Canadian ice hockey defenceman Gaston Dufresne (1898–1998), contrabassist in the Boston Symphony Orchestra Gérard Dufresne (1918–2013), politician and military officer in Quebec Guillaume Dufresne d'Arsel, who established French rule of Mauritius Jean Dufresne (1829–1893), German chess player John Dufresne (born 1948), American author of French-Canadian descent Joseph Dufresne (1805–1873), Quebec notary and political figure Laurent Dufresne (born 1972), former French football team captain Louis Dufresne (1752–1832), French explorer, ornithologist and taxidermist Marc-Joseph Marion du Fresne (1724–1772), French explorer Nicole duFresne (1977–2005), American playwright and actress Wylie Dufresne (born 1970), chef and restaurant owner in Manhattan
Fictional people Andy Dufresne, the protagonist of the film The Shawshank Redemption and the novella the film is based on Frank 'Doc' DuFresne, a character in the web television series Red vs. Blue