VDE may refer to:
Science and technology Virtual Distributed Ethernet, a virtualised network infrastructure Violaxanthin de-epoxidase, an enzyme Visteon Dockable Entertainment, a portable DVD player with Game Boy Advance slot
Other uses VDE e.V. (Verband der Elektrotechnik, Elektronik und Informationstechnik), a German technical association German Unification Transport Projects (German initials "VDE"), transportation infrastructure projects