Big Hole may refer to:
The Big Hole, a former open-pit mine in Kimberley, South Africa Big Hole National Battlefield, a memorial in Montana, United States Big Hole (Oregon), a large explosion crater in Lake County, Oregon Battle of the Big Hole, a battle during the Nez Perce War of 1877 Big Hole Pass, a high mountain pass in Montana Big Hole National Forest, a former National Forest in Montana and Idaho Big Hole River