James Irwin (1930–1991) was an Apollo 15 astronaut who walked on the Moon.
James or Jim Irwin may also refer to: James Murray Irwin (1858–1938), British Army doctor James Alexander Hamilton Irwin, Irish Presbyterian minister James Campbell Irwin (1906–1990), Australian soldier and architect, Lord Mayor of Adelaide James C. Irwin (1929–2018), United States Coast Guard admiral Jamie Irwin (James Campbell Irwin, 1937–2005), South Australian politician Jim Irwin (sportscaster) (1934–2012), American sportscaster in Wisconsin James Irwin, American singer in The Voice (U.S. season 5) in 2013
See also James Irwin Brownson (1816–1899), American Presbyterian clergyman and academic in Pennsylvania James Irwin Hartt (1866–1935), Irish-born Canadian lumberman and political figure in Ontario