Isham is a surname. Notable people with the surname include:
Isham Baronets of Lamport Hall in the County of Northamptonshire, including: Sir John Isham, 1st Baronet (1582–1651) Sir Justinian Isham, 2nd Baronet (1610–1675) Sir Thomas Isham, 3rd Baronet (1656–1681) Sir Justinian Isham, 4th Baronet (1658–1730) Sir Justinian Isham, 5th Baronet (1687–1737) Sir Edmund Isham, 6th Baronet (1690–1772) Sir Justinian Isham, 7th Baronet (1740–1818) Sir Charles Edmund Isham, 10th Baronet (1819–1903) Sir Gyles Isham, 12th Baronet (1903–1976)
Ashley Isham (b. 1976), fashion designer Charles Bradford Isham (1853–1919), American historian Christopher Isham (b. 1944), theoretical physicist Edmund Isham (1744?–1817), administrator at the University of Oxford Elizabeth Isham (c.1608–1654), English writer Euseby Isham, Rector of Lincoln College, Oxford Frederic S. Isham (1865–1922), American novelist and playwright Heyward Isham (1926–2009), international negotiator John Isham (disambiguation), several people John William Isham (1866–1902), American vaudeville impresario Mamie Lincoln Isham (1896–1938), granddaughter of Abraham Lincoln Mark Isham (b. 1951), American musician Mary Isham, wife of William Randolph Norman Isham (1864–1943), American architectural historian Samuel Isham (1855–1914), American painter Wayne Isham (b. 1958), video director Willard W. Isham (1820–1876), American politician William Bradley Isham (1827–1909), American banker Zacheus Isham (1651–1705), British clergyman and religious author
Places Isham, village in Northamptonshire, England Isham, Tennessee, unincorporated community, United States