546 may refer to:
the year 546 AD the year 546 BC
Any of the following American roads: KY 546, a former state highway in Kentucky LA 546, a state highway in Louisiana Route 546, a state highway in Maryland CR546, a county route in the state of New Jersey Erie County Route 546, a county route in the state of New York Route 546, a state highway in Ohio Route 546, a state highway in Pennsylvania Route 546, a state highway in Washington
Or, Secondary Highway 546 in the Algoma District of Ontario, Canada.