Saint Denys River (French: Rivière Denys) is a river in Nunavik, Quebec, Canada. It originates on Lac Silvy at . It flows through Lac Marest, Lac Denys and many challenging rapids until it joins Great Whale River at .

Northern (longer) branch of the river (unnamed on topographic maps) originates much more east, on Lac Dervilliers at , elevation .

Apart from local Inuit and Cree, Saint Denys River was first explored in 1888 by Albert Peter Low.

River is named after 3rd-century Christian martyr, the patron of Paris.

Bonaventure Enterprises Inc. is doing extensive drilling for K9 Uranium on the north shore of Saint Denys River (2008).

See also Saint Denys River Expedition 2002

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