Mathis is a surname and a given name. It may also refer to:
Mathis, Missouri, an unincorporated community Mathis, Texas, United States, a city Mathis Independent School District, a public school district Mathis Spur, Queen Elizabeth Land, Antarctica Mathis Nunataks, Marie Byrd Land, Antarctica Mathis Airport, Georgia, United States, a private airport Mathis (cars), a firm in Alsace which produced cars between 1910 and 1950