William Best may refer to:
William Best (cricketer) (1865–1942), English cricketer William Thomas Best (1826–1897), English organist William Best, 1st Baron Wynford (1767–1845), British politician and judge William Best, 2nd Baron Wynford (1798–1869), British peer William Best (Nova Scotia politician) (1707–1782), Nova Scotia politician, one of the founders of Halifax William Best, composed the music for the song "(I Love You) For Sentimental Reasons" Willie Best (1916–1962), American television and film actor
See also John William Best (1912–2000), British Royal Air Force pilot